Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6470098 | 0.89 | POLB (0.46) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL7744607 | 0.88 | POLB (0.57) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL7750046 | 0.87 | POLB (0.45) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL6447443 | 0.87 | POLB (0.45) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL8368905 | 0.84 | KMT2A (0.43) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL8367979 | 0.83 | HTT (0.47) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL8368924 | 0.83 | ENPP3 (0.46) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL8366661 | 0.82 | MEN1 (0.38) | CYP2C19VDRALDH1A1KMT2AMEN1 | |
| SCHEMBL7749117 | 0.82 | ALDH1A1 (0.51) | POLBCYP2C19HDAC3HDAC1HDAC2 | |
| SCHEMBL8368908 | 0.82 | ADORA3 (0.47) | POLBCYP2C19ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465489-B1 | SUCH AS 1-BENZOYL-3-(3,4-DICHLOROPHENYL)-3-(3-(4-(N',N'-DIMETHYLUREIDO)-4 -PHENYLPIPERIDIN-1-)PROPYL)PIPERIDINE; PSYCHIATRIC AND PSYCHOSOMATIC ILLNESSES, HYPERTENSION, CENTRAL OR PERIPHERAL PATHOLOGY | SANOFI-SYNTHELABO (FR) | 2002-10-15 | — | — | US | disclosed |