Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218234 | 0.83 | SLC6A2 (0.41) | TAAR1SLC6A2DHFRKCNH2CYP2D6 | |
| SCHEMBL9806910 | 0.79 | HSP90AA1 (0.41) | TAAR1SLC6A2KCNH2CYP2D6CYP1A2 | |
| SCHEMBL1466372 | 0.75 | FFAR1 (0.42) | LMNAHSP90AA1HSP90AB1SMN1; SMN2HIF1A | |
| SCHEMBL3888886 | 0.74 | CALM1 (0.50) | TAAR1KCNH2CYP1A2CYP3A4TP53 | |
| SCHEMBL28760837 | 0.72 | CYP1A2 (0.39) | DHFRKCNH2CYP1A2LMNATP53 | |
| SCHEMBL31257844 | 0.71 | APP (0.50) | TAAR1SLC6A2KCNH2CYP1A2CYP3A4 | |
| SCHEMBL185558 | 0.70 | TP53 (0.43) | TAAR1SLC6A2DHFRKCNH2CYP2D6 | |
| SCHEMBL3508191 | 0.70 | LOXL2 (0.43) | TAAR1DHFRKCNH2CYP1A2CYP3A4 | |
| SCHEMBL9574147 | 0.70 | IDO1 (0.45) | LMNASIGMAR1 | |
| SCHEMBL9856631 | 0.69 | CALM1 (0.45) | TAAR1DHFRKCNH2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020052509-A1 | Calcilytic compounds and method of use | SMITHKLINE BEECHAM CORPORATION | 2002-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052509-A1 | Calcilytic compounds and method of use | SOST, CALCR, PTH1R | TAAR1 3847/4885SLC6A2 2365/4885DHFR 2861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.