SCHEMBL7679666

SCHEMBL7679666

Cc1ccc(S(=O)(=O)NC(CC(=O)O)C(=O)Cn2nnc(Cc3c(Cl)cccc3Cl)n2)cc1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 5/20 0.43
PSMB8 P28062 6/20 0.41
PSMB5 P28074 4/20 0.41
TDP1 Q9NUW8 1/20 0.38
MMP2 P08253 3/20 0.38
MMP13 P45452 3/20 0.38
MMP3 P08254 2/20 0.38
ADAMTS4 O75173 2/20 0.38
KMT2A Q03164 1/20 0.38
CNR2 P34972 2/20 0.38
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
RECQL P46063 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
MMP1 P03956 1/20 0.37
MMP7 P09237 1/20 0.37
MMP8 P22894 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7686355 0.93 MMP9 (0.44) MMP9MMP2MMP13ADAMTS4CNR2
SCHEMBL7683595 0.93 MMP2 (0.44) MMP9MMP2MMP13MMP3ADAMTS4
SCHEMBL7678024 0.93 CNR2 (0.40) MMP9MMP2MMP13ADAMTS4CNR2
SCHEMBL7680110 0.92 ITGB3 (0.37) MMP9PSMB8PSMB5ADAMTS4CNR2
SCHEMBL7686256 0.92 MMP9 (0.40) MMP9MMP2MMP13MMP3ADAMTS4
SCHEMBL7686108 0.91 MMP2 (0.42) MMP9MMP2MMP13MMP3ADAMTS4
SCHEMBL7682261 0.91 ALDH1A1 (0.37) MMP9MMP2MMP13MMP3ADAMTS4
SCHEMBL7684559 0.91 MMP2 (0.39) MMP9MMP2MMP13MMP3ADAMTS4
SCHEMBL7687017 0.91 MMP2 (0.39) MMP9MMP2MMP13ADAMTS4CNR2
SCHEMBL7676860 0.91 SMN1; SMN2 (0.43) MMP9MMP2MMP13ADAMTS4KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US claimed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP claimed
US-6376484-B1 FOR PREVENTION AND/OR TREATMENT OF VARIOUS KINDS OF INFLAMMATORY DISEASE ONO PHARMACEUTICAL CO., LTD. (JP) 2002-04-23 US disclosed
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP disclosed