Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 18/20 | 0.74 |
| ▸ | BCHE | P06276 | 15/20 | 0.74 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550502 | 0.81 | KDM4E (0.66) | ACHEBCHETTRKDM4EALDH1A1 | |
| SCHEMBL7769407 | 0.80 | HRH3 (0.57) | ACHEBCHE | |
| SCHEMBL7676833 | 0.80 | HSP90AA1 (0.61) | ACHEBCHEKDM4EALDH1A1KMT2A | |
| SCHEMBL2224754 | 0.79 | APP (0.67) | ACHEBCHETTRKDM4EALDH1A1 | |
| SCHEMBL19358969 | 0.79 | APP (0.69) | ACHEBCHETTR | |
| SCHEMBL2224756 | 0.79 | APP (0.67) | ACHEBCHETTRKDM4EALDH1A1 | |
| SCHEMBL19358971 | 0.79 | APP (0.69) | ACHEBCHETTR | |
| SCHEMBL2453913 | 0.78 | ACHE (0.56) | ACHEBCHEKDM4E | |
| SCHEMBL2453910 | 0.78 | ACHE (0.56) | ACHEBCHEKDM4E | |
| SCHEMBL25196911 | 0.78 | ACHE (0.68) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500823-B1 | ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES | N-GENE RESEARCH LABORATORIES, INC. | 2002-12-31 | — | — | US | claimed |