Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ribose (Furanose). The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribose (Furanose) SCHEMBL831005 | 1.00 | CYP3A4 (0.39) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Ribose (Furanose) SCHEMBL8605925 | 0.87 | ADK (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Ribose (Furanose) SCHEMBL17824409 | 0.87 | ADK (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Ribose (Furanose) SCHEMBL4542672 | 0.87 | ADK (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Ribose (Furanose) SCHEMBL1531264 | 0.84 | HSD17B10 (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Adenine SCHEMBL7746165 | 0.84 | PI4KA (0.58) | CYP3A4HIF1ALMNAHTTPI4KA | |
| Ribose (Furanose) SCHEMBL12542065 | 0.84 | HSD17B10 (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Ribose (Furanose) SCHEMBL1682946 | 0.84 | HSD17B10 (0.40) | CYP3A4HIF1AHSD17B10LMNAHTT | |
| Adenine SCHEMBL38386 | 0.84 | PI4KA (0.58) | CYP3A4HIF1ALMNAHTTPI4KA | |
| Adenine SCHEMBL7624128 | 0.84 | PI4KA (0.58) | CYP3A4HIF1ALMNAHTTPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020061509-A1 | Screening assay for the identification of agents which alter expression of PTH-rP | OSTEO SCREEN | 2002-05-23 | — | — | US | disclosed |
| US-5914233-A | TRANSFORMATION OF TUMOR CELL LINES WITH EXPRESSION VECTOR ENCODING A PROMOTER REGION OF PARATHYROID HORMONE (PTH) LINKED TO REPORTER GENE ENCODING ASSAYABLE CULTURE PRODUCT | OSTEO SCREEN (US) | 1999-06-22 | — | — | US | disclosed |
| WO-1998007844-A2 | SCREENING ASSAY FOR THE IDENTIFICATION OF AGENTS WHICH ALTER EXPRESSION OF PTH-rP | OSTEOSCREEN (US) | 1998-02-26 | — | — | WO | disclosed |
| US-5213972-A | Production of thymidine and deoxyuridine, intermediates for AZT | CHEMGEN CORPORATION (US) | 1993-05-25 | — | — | US | disclosed |