Ribose (Furanose)

Ribose (Furanose)

SCHEMBL831005

OC[C@H]1OC(O)[C@H](O)[C@@H]1O.Sc1ncnc2nc[nH]c12

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPAT

The experimentally established mechanism targets of Ribose (Furanose). The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
HIF1A Q16665 3/20 0.38
HSD17B10 Q99714 3/20 0.37
LMNA P02545 2/20 0.37
HTT P42858 1/20 0.37
PI4KA P42356 2/20 0.36
PI4K2B Q8TCG2 2/20 0.36
PI4K2A Q9BTU6 2/20 0.36
PI4KB Q9UBF8 2/20 0.36
LRRK2 Q5S007 2/20 0.36
DRD3 P35462 1/20 0.36
XDH P47989 1/20 0.36
PNP P00491 1/20 0.36
CYP1A2 P05177 2/20 0.36
CDK2 P24941 2/20 0.36
G6PD P11413 1/20 0.36
CDC7 O00311 1/20 0.35
DBF4 Q9UBU7 1/20 0.35
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ribose (Furanose) SCHEMBL7680729 1.00 CYP3A4 (0.39) CYP3A4HIF1AHSD17B10LMNAHTT
Ribose (Furanose) SCHEMBL17824409 0.87 ADK (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Ribose (Furanose) SCHEMBL8605925 0.87 ADK (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Ribose (Furanose) SCHEMBL4542672 0.87 ADK (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Ribose (Furanose) SCHEMBL1682946 0.84 HSD17B10 (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Ribose (Furanose) SCHEMBL12542065 0.84 HSD17B10 (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Adenine SCHEMBL38386 0.84 PI4KA (0.58) CYP3A4HIF1ALMNAHTTPI4KA
Adenine SCHEMBL7746165 0.84 PI4KA (0.58) CYP3A4HIF1ALMNAHTTPI4KA
Ribose (Furanose) SCHEMBL1531264 0.84 HSD17B10 (0.40) CYP3A4HIF1AHSD17B10LMNAHTT
Adenine SCHEMBL7624128 0.84 PI4KA (0.58) CYP3A4HIF1ALMNAHTTPI4KA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2017278-B1 DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE MSD KK (JP) 2016-11-02 EP claimed
EP-2376493-B1 DIHYDROPYRIMIDOPYRIMIDINE DERIVATIVE MSD KK (JP) 2016-10-05 EP claimed
EP-2168966-B1 BICYCLOANILINE DERIVATIVE MSD KK (JP) 2016-09-28 EP claimed
EP-2648509-B1 SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LTD (IN) 2015-04-29 EP claimed
EP-2640392-B1 SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO)PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LTD (IN) 2015-01-07 EP claimed
EP-2254888-B1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION MSD KK (JP) 2014-12-24 EP claimed
EP-2017279-B1 AMINOPYRIMIDINE DERIVATIVES HAVING AURORA-A-SELECTIVE INHIBITORY ACTIVITY MSD KK (JP) 2013-09-04 EP claimed
EP-1813609-B1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING SELECTIVE AURORA-A INHIBITORY EFFECT MSD KK (JP) 2013-06-19 EP claimed
EP-2213673-B1 PYRIDONE-SUBSTITUTED-DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE MSD KK (JP) 2013-06-05 EP claimed
EP-1828165-B1 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION MSD KK (JP) 2013-03-20 EP claimed
EP-2016080-B1 DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES BANYU PHARMA CO LTD (JP) 2010-07-28 EP claimed
US-7247721-B2 Providing a mixture comprising nucleic acids and a charged material comprising any cationic purine; contacting the mixture and a surface to produce a bound material, wherein the bound material comprises nucleic acids covalenty bounded to the surface LYLES MARK B 2007-07-24 US claimed
US-20050148067-A1 Materials and methods for binding nucleic acids to surfaces LYLES MARK B (US) 2005-07-07 US claimed
EP-1305328-A2 MATERIALS AND METHODS FOR BINDING NUCLEIC ACIDS TO SURFACES Lyles, Mark B. (US) 2003-05-02 EP claimed
US-20020103350-A1 Materials and methods for binding nucleic acids to surfaces LYLES MARK B (US) 2002-08-01 US claimed
WO-2002008237-A2 MATERIALS AND METHODS FOR BINDING NUCLEIC ACIDS TO SURFACES LYLES MARK B (US) 2002-01-31 WO claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
EP-0673783-B1 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORP (US) 2000-07-05 EP claimed
EP-0038541-B1 NOVEL PRODRUGS OF BIOLOGICALLY ACTIVE AGENTS CONTAINING MERCAPTO GROUPS, PROCESS FOR PREPARING AND THERAPEUTICALLY EFFECTIVE COMPOSITION CONTAINING THE SAME MERCK & CO. INC. (US) 1986-08-13 EP claimed