Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | GNRHR | P30968 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTPRG | P23470 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680104 | 0.86 | TUBB4A (0.46) | KMT2AMAPTHTTNPSR1PARP15 | |
| SCHEMBL7680945 | 0.72 | PTPRC (0.44) | LMNAMAPTDAOPTPRCPTPRG | |
| SCHEMBL1244218 | 0.71 | TNKS2 (0.43) | KMT2ADAOPARP15PARP10TNKS2 | |
| SCHEMBL23327755 | 0.67 | GPR35 (0.54) | KMT2AHTTDAOPARP15PARP10 | |
| SCHEMBL1244205 | 0.66 | TNKS2 (0.44) | KMT2ADAOPARP15PARP10TNKS2 | |
| SCHEMBL1244639 | 0.65 | GPR35 (0.45) | KMT2ANPSR1DAOPARP15PARP10 | |
| SCHEMBL2679084 | 0.65 | MAPT (0.54) | KMT2ALMNAMAPTS1PR4S1PR1 | |
| SCHEMBL30343460 | 0.65 | MAPT (0.54) | KMT2ALMNAMAPTS1PR4S1PR1 | |
| SCHEMBL8962319 | 0.64 | LMNA (0.56) | KMT2ALMNAACLYTSHR | |
| SCHEMBL23327628 | 0.64 | NEK1 (0.38) | KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| EP-1056451-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | AstraZeneca UK Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999040914-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |