Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679054 | 0.84 | HTR2C (0.45) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL7685135 | 0.81 | TP53 (0.46) | KDM4EPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30368251 | 0.80 | MAP1LC3B (0.57) | HTR2CMAP1LC3BTP53RECQL | |
| SCHEMBL643845 | 0.80 | MAP1LC3B (0.57) | HTR2CMAP1LC3BTP53RECQL | |
| SCHEMBL21231846 | 0.80 | SLC6A2 (0.54) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL6794592 | 0.79 | SLC9A1 (0.43) | TP53RECQL | |
| SCHEMBL29648490 | 0.78 | CYP3A4 (0.46) | HTR2AHTR2CKDM4EPDE4APDE4B | |
| SCHEMBL6794027 | 0.78 | KDM1A (0.46) | TP53RECQL | |
| SCHEMBL30472850 | 0.78 | KDM4E (0.41) | HTR2AHTR2CHTR2BKDM4EPDE4A | |
| SCHEMBL2571867 | 0.77 | PTGDR2 (0.56) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |