Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 3/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363491 | 0.92 | TSHR (0.33) | DNM1TSHRTHRBALDH1A1CA12 | |
| SCHEMBL7115358 | 0.80 | FDPS (0.39) | — | |
| Hydrochloric Acid SCHEMBL7371395 | 0.78 | FDPS (0.37) | — | |
| SCHEMBL8107788 | 0.77 | DNM1 (0.35) | DNM1TSHRALDH1A1PLA2G1BPLA2G2A | |
| SCHEMBL8114586 | 0.77 | MMP1 (0.31) | TSHRPLA2G1BPLA2G2A | |
| SCHEMBL11872469 | 0.75 | PLA2G1B (0.38) | DNM1TSHRTHRBPLA2G1BPLA2G2A | |
| SCHEMBL3314077 | 0.74 | DNM1 (0.42) | DNM1TSHRTHRBCA12CA1 | |
| SCHEMBL3309868 | 0.72 | DNM1 (0.46) | DNM1TSHRTHRBCA12CA1 | |
| SCHEMBL25469904 | 0.72 | DNM1 (0.40) | DNM1TSHRTHRBCA12CA1 | |
| SCHEMBL2361412 | 0.72 | DNM1 (0.40) | DNM1TSHRTHRBALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489337-B1 | TREATMENT OF ALZHEIMER'S DISEASE, EPILEPSY, EATING DISORDERS, LEARNING AND MEMORY DISORDERS, MIGRAINE, SLEEP/WAKE DISORDERS, ALLERGIC RHINITIS, SCHIZOPHRENIA, MILD COGNITIVE IMPAIRMENT, AND ASTHMA | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-12-03 | — | — | US | disclosed |
| WO-2001074813-A2 | METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2001-10-11 | — | — | WO | disclosed |
| US-4871745-A | LOCAL ANESTHETICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |
| US-4791117-A | LOCAL ANTESTHETICS, ANTISECRETORY AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-12-13 | — | — | US | disclosed |
| EP-0261912-A2 | 2- or 3- Aryl substituted imidazo [1,2-a] pyridines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-03-30 | — | — | EP | disclosed |
| US-4727145-A | LOCAL ANESTHETICS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |