Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 13/20 | 0.46 |
| ▸ | ACHE | P22303 | 11/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688328 | 0.94 | ACHE (0.50) | NPC1RAB9AHTR4ACHEKDM4E | |
| SCHEMBL7682170 | 0.92 | NPC1 (0.50) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL2482136 | 0.92 | NPC1 (0.50) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL2481231 | 0.91 | NPC1 (0.48) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL7688492 | 0.87 | ACHE (0.44) | NPC1RAB9AHTR4ACHEALDH1A1 | |
| SCHEMBL6703732 | 0.81 | HTR4 (0.58) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL27598401 | 0.79 | HTR4 (0.48) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL7688094 | 0.79 | HTR4 (0.61) | NPC1RAB9AHTR4ACHESIGMAR1 | |
| SCHEMBL7688139 | 0.76 | NPC1 (0.67) | NPC1RAB9AHTR4ACHEMEN1 | |
| SCHEMBL2481341 | 0.73 | HTR4 (0.66) | HTR4ACHESIGMAR1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380230-B1 | FOR THERAPY OF DYSKINESIA, OBESITY, IRRITABLE BOWEL SYNDROME, DISEASES WHOSE TREATMENT REQUIRES STIMULATION OF THE CHOLECYSTOKININ CCK-A RECEPTORS | SANOFI-SYNTHELABO (FR) | 2002-04-30 | — | — | US | disclosed |
| EP-1017693-A1 | CARBOXAMIDOTHIAZOLE DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI-SYNTHELABO (FR) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015525-A1 | CARBOXAMIDOTHIAZOLE DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI-SYNTHELABO (FR) | 1999-04-01 | — | — | WO | disclosed |