Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675831 | 0.83 | KMT2A (0.47) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL2253649 | 0.78 | LMNA (0.64) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL1449661 | 0.78 | LMNA (0.64) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL2701951 | 0.77 | LMNA (0.62) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL27957193 | 0.75 | LMNA (0.60) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL3286254 | 0.75 | LMNA (0.60) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL6057354 | 0.75 | LMNA (0.66) | LMNAALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL130761 | 0.75 | LMNA (1.00) | LMNAALDH1A1HPGDSMN1; SMN2TDP1 | |
| SCHEMBL27624901 | 0.75 | TSHR (0.39) | LMNAALDH1A1HPGDTDP1TSHR | |
| SCHEMBL7181498 | 0.75 | LMNA (1.00) | LMNAALDH1A1HPGDSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448259-B1 | CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR GAMMA AMINOBUTYRIC ACID BINDING SITE, THE BENZODIAZEPINE RECEPTOR; ANXIETY, SLEEP AND SEIZURE DISORDERS SEDATIVE, ANXIOLYTIC AND ANTICONVULSANT ACTIVITY | NEUROGEN CORPORATION | 2002-09-10 | — | — | US | claimed |