Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675831 | 0.78 | KMT2A (0.47) | TSHRLMNAKMT2APOLBHPGD | |
| SCHEMBL7682290 | 0.75 | LMNA (0.60) | TSHRLMNAHTTKMT2ATDP1 | |
| SCHEMBL27606820 | 0.75 | ALDH1A1 (0.41) | TSHRLMNAMAPK1HTTL3MBTL1 | |
| SCHEMBL514540 | 0.75 | LMNA (0.60) | TSHRLMNAMAPK1L3MBTL1KMT2A | |
| SCHEMBL3578945 | 0.75 | TSHR (0.52) | TSHRLMNAMAPK1HTTKMT2A | |
| Benzil SCHEMBL27395782 | 0.70 | CES2 (0.64) | TSHRL3MBTL1AKT1HPGDCES2 | |
| SCHEMBL31088171 | 0.69 | MAPT (0.51) | TSHRLMNAMAPK1HTTL3MBTL1 | |
| P-Xylene SCHEMBL28048503 | 0.69 | NPC1 (0.63) | TSHRLMNAMAPK1KMT2ATDP1 | |
| SCHEMBL14287513 | 0.69 | LMNA (0.53) | TSHRLMNAMAPK1L3MBTL1KMT2A | |
| SCHEMBL11358478 | 0.69 | LMNA (0.53) | TSHRLMNAMAPK1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |