SCHEMBL23409587

SCHEMBL23409587

OCc1c(Cl)cc(O)c(F)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 8/20 0.38
TSHR P16473 7/20 0.38
HPGD P15428 6/20 0.38
CYP3A4 P08684 4/20 0.38
HSP90AA1 P07900 2/20 0.38
ALOX15 P16050 2/20 0.33
ALOX12 P18054 2/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
USP2 O75604 1/20 0.33
EGFR P00533 1/20 0.33
LMNA P02545 1/20 0.33
ESR1 P03372 1/20 0.33
ERBB2 P04626 1/20 0.33
CYP1A2 P05177 1/20 0.33
LCK P06239 1/20 0.33
FYN P06241 1/20 0.33
PGR P06401 1/20 0.33
POLB P06746 1/20 0.33
HTR1A P08908 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29970962 1.00 HSD17B10 (0.38) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL29971157 0.83 TAAR1 (0.33) HSD17B10CYP3A4ADRA2AADRA2CADRA1A
SCHEMBL23409459 0.83 TAAR1 (0.33) HSD17B10CYP3A4ADRA2AADRA2CADRA1A
SCHEMBL25949817 0.82 HSD17B10 (0.37) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL23409568 0.80 HSD17B10 (0.54) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL23409499 0.80 DRD4 (0.30)
SCHEMBL23409597 0.80 ALDH1A1 (0.36) HSD17B10HPGDCYP3A4ALOX15ALOX12
SCHEMBL29970645 0.80 DRD4 (0.34) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL23409399 0.80 DRD4 (0.34) HSD17B10TSHRHPGDCYP3A4HSP90AA1
SCHEMBL23409465 0.80 TSHR (0.33) HSD17B10TSHRHPGDCYP3A4HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12528761-B2 Thyromimetics AUTOBAHN THERAPEUTICS, INC. (US) 2026-01-20 US disclosed
US-12466781-B2 Thyromimetics AUTOBAHN THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
US-20230242471-A1 THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. 2023-08-03 US disclosed
EP-4168384-A1 THYROMIMETICS Autobahn Therapeutics, Inc. (US) 2023-04-26 EP disclosed
CN-115916740-A Thyromimetic agents 速通医疗公司 2023-04-04 CN disclosed
US-20230048992-A1 NOVEL THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. 2023-02-16 US disclosed
US-20230048992-A1 NOVEL THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. 2023-02-16 US disclosed
CN-115279359-A Novel thyromimetic agents 速通医疗公司 2022-11-01 CN disclosed
EP-4065098-A1 NOVEL THYROMIMETICS Autobahn Therapeutics, Inc. (US) 2022-10-05 EP disclosed
WO-2021257851-A1 THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. (US) 2021-12-23 WO disclosed
WO-2021108549-A1 NOVEL THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. (US) 2021-06-03 WO disclosed
WO-2021108549-A1 NOVEL THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. (US) 2021-06-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230048992-A1 NOVEL THYROMIMETICS TSHR, TPO, CHRM1 HSD17B10 1433/4885TSHR 1/4885HPGD 558/4885
US-12466781-B2 Thyromimetics TPO, TSHR, CHRM1 HSD17B10 1760/4885TSHR 2/4885HPGD 454/4885
US-12528761-B2 Thyromimetics TSHR, THRB, TTR HSD17B10 870/4885TSHR 1/4885HPGD 1708/4885
US-20230242471-A1 THYROMIMETICS TPO, THOP1, THRB HSD17B10 1340/4885TSHR 4/4885HPGD 259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.