Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788846 | 0.88 | TDP1 (0.44) | TDP1MAPK1CYP19A1NQO2ALDH1A1 | |
| SCHEMBL4847168 | 0.75 | CYP3A4 (0.59) | TDP1MAPK1ALDH1A1CYP3A4APP | |
| SCHEMBL27880134 | 0.73 | PDE4B (0.52) | MAPK1ALDH1A1CYP3A4KDM4ENPC1 | |
| SCHEMBL1484214 | 0.72 | TDP1 (0.36) | TDP1MAPK1CYP19A1NQO2ALDH1A1 | |
| SCHEMBL24561 | 0.69 | TDP1 (0.67) | TDP1MAPK1ALDH1A1CYP3A4APP | |
| SCHEMBL3841534 | 0.68 | PDE4B (0.50) | MAPK1ALDH1A1KDM4ENPC1MAPT | |
| SCHEMBL6020612 | 0.67 | CYP3A4 (0.62) | TDP1MAPK1ALDH1A1CYP3A4APP | |
| Benzidine SCHEMBL28611518 | 0.67 | TDP1 (0.73) | TDP1MAPK1ALDH1A1CYP3A4APP | |
| SCHEMBL14656326 | 0.67 | ALDH1A1 (0.48) | TDP1MAPK1CYP19A1ALDH1A1CYP3A4 | |
| SCHEMBL9489154 | 0.67 | KDM4E (0.37) | TDP1MAPK1CYP19A1NQO2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020082432-A1 | New podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082432-A1 | New podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore | TOP2A, TOP2B, PCNA | TDP1 65/4885MAPK1 3805/4885CYP19A1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.