Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689241 | 0.86 | HCAR2 (0.48) | HSD17B10ALOX15TSHRMAPTLMNA | |
| SCHEMBL7683237 | 0.84 | SMN1; SMN2 (0.48) | TSHRMAPTLMNASMN1; SMN2RXFP1 | |
| SCHEMBL7683547 | 0.82 | MAP1LC3B (0.50) | TSHRLMNASMN1; SMN2USP2PKM | |
| SCHEMBL7689368 | 0.74 | PIM1 (0.45) | ALOX15TSHRMAPTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7687556 | 0.74 | LMNA (0.35) | HSD17B10LMNAHTTHCAR2TP53 | |
| Hydrochloric Acid SCHEMBL7687559 | 0.74 | LMNA (0.35) | HSD17B10LMNAHTTHCAR2TP53 | |
| Hydrochloric Acid SCHEMBL7687660 | 0.73 | PIM1 (0.44) | ALOX15TSHRMAPTLMNASMN1; SMN2 | |
| SCHEMBL7481463 | 0.72 | HCAR2 (0.45) | HSD17B10ALOX15TSHRMAPTLMNA | |
| SCHEMBL4620173 | 0.72 | HSP90AA1 (0.69) | HSD17B10TSHRMAPTLMNASMN1; SMN2 | |
| SCHEMBL7682930 | 0.71 | MAPT (0.44) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |