SCHEMBL7683237

SCHEMBL7683237

Cc1n[nH]c2c1C(=O)CC(c1ccccc1Cl)C2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.48
ALDH1A1 P00352 2/20 0.48
LMNA P02545 2/20 0.48
HTT P42858 2/20 0.48
RXFP1 Q9HBX9 1/20 0.48
USP2 O75604 1/20 0.48
PKM P14618 1/20 0.48
TP53 P04637 2/20 0.47
MAPT P10636 1/20 0.47
RECQL P46063 1/20 0.47
HCAR2 Q8TDS4 2/20 0.46
MAPK1 P28482 2/20 0.42
LDHA P00338 1/20 0.41
LDHB P07195 1/20 0.41
ADRA1A P35348 1/20 0.40
KDM4E B2RXH2 1/20 0.40
XBP1 P17861 1/20 0.40
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
ERBB2 P04626 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689241 0.86 HCAR2 (0.48) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7689368 0.85 PIM1 (0.45) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7682852 0.84 HSD17B10 (0.39) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7689472 0.84 LMNA (0.47) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
Hydrochloric Acid SCHEMBL7687660 0.84 PIM1 (0.44) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7683547 0.82 MAP1LC3B (0.50) SMN1; SMN2LMNAHTTUSP2PKM
SCHEMBL7682873 0.82 HCAR2 (0.50) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7681257 0.81 SMN1; SMN2 (0.45) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7682652 0.79 HCAR2 (0.42) SMN1; SMN2ALDH1A1LMNAHTTRXFP1
SCHEMBL7689388 0.78 TP53 (0.34) SMN1; SMN2ALDH1A1LMNAHTTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6350749-B1 SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-02-26 US disclosed
EP-1057812-A1 AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-12-06 EP disclosed