Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 18/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906631 | 0.88 | CTSK (0.48) | KIF11PPARGPPARA | |
| SCHEMBL5276867 | 0.88 | CTSK (0.48) | KIF11PPARGPPARA | |
| SCHEMBL8372894 | 0.83 | KIF11 (0.48) | KIF11DNMT1PPARGPPARA | |
| SCHEMBL28812175 | 0.79 | ATM (0.53) | PPARA | |
| SCHEMBL18549299 | 0.78 | PPARA (0.45) | KIF11PPARGPPARA | |
| SCHEMBL18549277 | 0.78 | PPARA (0.45) | KIF11PPARGPPARA | |
| SCHEMBL7749265 | 0.77 | KIF11 (0.59) | KIF11DNMT1 | |
| SCHEMBL619354 | 0.75 | PPARA (0.61) | KIF11DNMT1PPARGPPARA | |
| SCHEMBL8741673 | 0.75 | KIF11 (0.47) | KIF11DNMT1PPARGPPARA | |
| SCHEMBL21084961 | 0.75 | PPARA (0.61) | KIF11DNMT1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500841-B1 | ADMINISTERING ENZYME/TRANSFERASE INHIBITORS SUCH AS N-(N-(AMINO-3-MERCAPTOPROPYLAMINO)-3-METHYLPENTYL)-1,2,3,4-TETRAHYDRO-3 -ISOQUINOLINECARBOXYL)-METHIONINE METHYL ESTER, AS ANTICARCINOGENIC AGENTS OR PRODRUGS | MERCK & CO., INC. | 2002-12-31 | — | — | US | disclosed |
| EP-0755383-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1997-08-27 | — | — | EP | disclosed |
| EP-0755383-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5536750-A | ANTITUMOR | MERCK & CO., INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0668856-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE. | MERCK & CO INC (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1995025092-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1995-09-21 | — | — | WO | disclosed |
| EP-0668856-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1995-08-30 | — | — | EP | disclosed |
| US-5439918-A | Prodrug for cancer therapy | MERCK & CO., INC. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5326773-A | Prodrug enzyme inhibitors | MERCK & CO., INC. (US) | 1994-07-05 | — | — | US | disclosed |
| WO-1994010137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |