Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573531 | 0.85 | EPHX2 (0.45) | KMT2AMEN1ANPEPERAP2CYP2D6 | |
| SCHEMBL21799683 | 0.84 | TPSAB1 (0.42) | TPSAB1KMT2AMEN1ANPEPERAP2 | |
| SCHEMBL2013167 | 0.80 | MEN1 (0.57) | KMT2AMEN1CYP3A4LMNAHTT | |
| SCHEMBL21800101 | 0.79 | ANPEP (0.39) | TPSAB1KMT2AMEN1ANPEPERAP2 | |
| SCHEMBL23160258 | 0.78 | LMNA (0.61) | KMT2AMEN1ANPEPERAP2LMNA | |
| SCHEMBL2581883 | 0.76 | LOXL2 (0.43) | TPSAB1KMT2AANPEPERAP2CYP2D6 | |
| SCHEMBL21799653 | 0.73 | OPRM1 (0.40) | TPSAB1KMT2AMEN1ANPEPERAP2 | |
| SCHEMBL19580441 | 0.73 | LOXL2 (0.50) | ABATLOXL2HRH3SMN1; SMN2NOS3 | |
| SCHEMBL8397161 | 0.73 | TPSAB1 (0.47) | TPSAB1ANPEPERAP2CYP2D6CYP2C9 | |
| SCHEMBL24818858 | 0.72 | HTT (0.35) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |