Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26551923 | 0.85 | HRH3 (0.39) | ABATF11HRH3NOS3NOS1 | |
| SCHEMBL24522210 | 0.81 | ALDH1A1 (0.46) | NR1H2NR1H3ALDH1A1CYP3A4TSHR | |
| SCHEMBL12176448 | 0.79 | ALDH1A1 (0.44) | NR1H2NR1H3ALDH1A1TSHRTDP1 | |
| SCHEMBL11556871 | 0.76 | MEN1 (0.41) | NR1H2NR1H3ALDH1A1CYP3A4TSHR | |
| SCHEMBL24543107 | 0.75 | RET (0.36) | HRH3NR1H2NR1H3ALDH1A1TSHR | |
| SCHEMBL23160256 | 0.74 | AOC3 (0.51) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14196578 | 0.73 | L3MBTL1 (0.44) | ABATF11HRH3NOS3NOS1 | |
| SCHEMBL7681662 | 0.73 | NR1H3 (0.40) | HRH3NOS3NOS1LOXL2NR1H2 | |
| SCHEMBL19580441 | 0.71 | LOXL2 (0.50) | ABATF11HRH3NOS3NOS1 | |
| SCHEMBL14146949 | 0.71 | KEAP1 (0.52) | ABATHRH3NOS1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |