Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962181 | 0.85 | ACE2 (0.43) | PRKCIACHEACE2ALDH1A1EPHX2 | |
| SCHEMBL30279132 | 0.84 | PRKCI (0.40) | PRKCIACHEALDH1A1KDM4EGABRA1 | |
| SCHEMBL25041795 | 0.84 | PRKCI (0.40) | PRKCIACHEALDH1A1KDM4EGABRA1 | |
| SCHEMBL9211984 | 0.78 | ALDH1A1 (0.41) | ACE2ALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL3820235 | 0.78 | GAA (0.50) | PRKCIACHEALDH1A1KDM4EGAA | |
| SCHEMBL30789314 | 0.78 | GAA (0.50) | PRKCIACHEALDH1A1KDM4EGAA | |
| SCHEMBL2814705 | 0.77 | ALDH1A1 (0.36) | PRKCIACHEALDH1A1KDM4EGAA | |
| SCHEMBL7369795 | 0.74 | ALDH1A1 (0.50) | ACHEALDH1A1KDM4EPGRGAA | |
| SCHEMBL18802756 | 0.73 | GABRA1 (0.36) | ACE2GABRA1GABRB2ESR1ESR2 | |
| SCHEMBL18156891 | 0.72 | KIF11 (0.44) | ALDH1A1PGRGAAMAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |