Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684882 | 1.00 | RIPK1 (0.42) | RIPK1PDE5ASLC9A1MAOAMAOB | |
| SCHEMBL7589602 | 0.81 | CHRNA7 (0.45) | RIPK1PDE5ASLC9A1MAOAMAOB | |
| SCHEMBL7589609 | 0.81 | CHRNA7 (0.45) | RIPK1PDE5ASLC9A1MAOAMAOB | |
| SCHEMBL7592025 | 0.77 | MAOA (0.44) | RIPK1PDE5AMAOAMAOBHTT | |
| SCHEMBL7592028 | 0.77 | MAOA (0.44) | RIPK1PDE5AMAOAMAOBHTT | |
| SCHEMBL7595211 | 0.66 | MAPT (0.40) | SLC9A1HTTMEN1ALDH1A1MAPT | |
| SCHEMBL7595212 | 0.66 | MAPT (0.40) | SLC9A1HTTMEN1ALDH1A1MAPT | |
| SCHEMBL20835380 | 0.66 | FFAR2 (0.51) | RIPK1PDE5ASLC9A1MAOAMAOB | |
| SCHEMBL24737484 | 0.65 | SLC9A1 (0.64) | SLC9A1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL31684359 | 0.65 | SLC9A1 (0.64) | SLC9A1MEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451789-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | LES LABORTOIRES SERVIER (FR) | 2002-09-17 | — | — | US | disclosed |
| US-6323222-B1 | COGNITION ACTIVATORS, ALZHEIMER*S DISEASE AND ENZYME INHIBITORS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |