Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | GFER | P55789 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.75 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | ESR1 | P03372 | 4/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.52 |
| ▸ | GLB1 | P16278 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049280 | 0.89 | MAPT (0.55) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL6343638 | 0.89 | MAPT (0.55) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL10942166 | 0.87 | MAPT (1.00) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL824903 | 0.87 | MAPT (1.00) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL17443 | 0.81 | — | — | |
| SCHEMBL6118114 | 0.81 | ALOX15 (1.00) | MAPTGFERHSD17B10ALOX15ESR1 | |
| SCHEMBL2287032 | 0.80 | MEN1 (0.54) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL2279014 | 0.79 | MAPT (0.58) | MAPTGFERHTTHSD17B10GPR55 | |
| Formaldehyde SCHEMBL9616525 | 0.78 | ALOX15 (0.81) | MAPTGFERHTTHSD17B10GPR55 | |
| SCHEMBL10076323 | 0.78 | MAPT (0.44) | MAPTGFERHTTHSD17B10GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| CN-1158844-A | Tertiary amines | HOFFMANN LA ROCHE (CH) | 1997-09-10 | — | — | CN | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |