Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 12/20 | 0.39 |
| ▸ | FEN1 | P39748 | 12/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686773 | 0.87 | TSHR (0.39) | PTGS2PTGS1 | |
| SCHEMBL7536004 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL7592378 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL7671604 | 0.76 | ALDH1A1 (0.35) | PTGS2PTGS1KCNQ3KCNQ2 | |
| SCHEMBL7674454 | 0.74 | PTGS2 (0.40) | PTGS2PTGS1 | |
| SCHEMBL6622930 | 0.72 | PTGS2 (0.46) | PTGS2PTGS1 | |
| SCHEMBL7536789 | 0.64 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL6620782 | 0.63 | PTGS2 (0.39) | PTGS2PTGS1 | |
| SCHEMBL7538974 | 0.63 | HAO2 (0.43) | — | |
| SCHEMBL7670565 | 0.62 | PTGS2 (0.52) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |