SCHEMBL7686886

SCHEMBL7686886

O=C(Nc1cccc(C(F)(F)F)c1)c1ccc2cccnc2c1O

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 7/20 0.77
MAPT P10636 4/20 0.66
KMT2A Q03164 6/20 0.56
MEN1 O00255 5/20 0.56
P2RX1 P51575 2/20 0.56
HTT P42858 4/20 0.55
ALDH1A1 P00352 3/20 0.55
L3MBTL1 Q9Y468 3/20 0.55
LMNA P02545 2/20 0.55
KDM4E B2RXH2 2/20 0.55
HSP90AA1 P07900 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
HPGD P15428 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
RXFP1 Q9HBX9 1/20 0.55
P2RX3 P56373 1/20 0.55
P2RX4 Q99571 1/20 0.55
P2RX7 Q99572 1/20 0.55
OPRK1 P41145 1/20 0.54
TDP1 Q9NUW8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8311076 0.91 EGLN1 (0.80) EGLN1MAPTP2RX1ALDH1A1P2RX3
Hydrochloric Acid SCHEMBL7683285 0.90 EGLN1 (0.79) EGLN1MAPTP2RX1ALDH1A1P2RX3
SCHEMBL3140634 0.88 MAPT (0.67) EGLN1MAPTKMT2AMEN1P2RX1
SCHEMBL19347362 0.87 EGLN1 (1.00) EGLN1MAPTP2RX1ALDH1A1P2RX3
SCHEMBL8309229 0.85 EGLN1 (0.73) EGLN1MAPTKMT2AMEN1ALDH1A1
Hydrochloric Acid SCHEMBL7691042 0.84 EGLN1 (0.71) EGLN1MAPTKMT2AMEN1ALDH1A1
SCHEMBL8312850 0.82 EGLN1 (0.73) EGLN1KMT2AMEN1P2RX1ALDH1A1
SCHEMBL7964145 0.82 EGLN1 (0.73) EGLN1KMT2AMEN1ALDH1A1
SCHEMBL7687778 0.82 EGLN1 (0.73) EGLN1KMT2AMEN1ALDH1A1
SCHEMBL7953380 0.82 EGLN1 (0.73) EGLN1KMT2AMEN1P2RX1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US claimed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP claimed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO claimed
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed