SCHEMBL7688219

SCHEMBL7688219

COC(c1ccc(Cl)cc1)c1ncc(C(F)(F)F)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.61
KMT2A Q03164 6/20 0.60
MEN1 O00255 4/20 0.60
LMNA P02545 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
MAPK1 P28482 1/20 0.53
ALDH1A1 P00352 1/20 0.49
PKM P14618 1/20 0.49
GAA P10253 4/20 0.48
MAPT P10636 2/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.44
TDP1 Q9NUW8 1/20 0.43
KDM4E B2RXH2 1/20 0.43
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7688112 0.79 KMT2A (0.76) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL7688138 0.79 MAPK1 (0.67) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL7688613 0.76 L3MBTL1 (1.00) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL7691426 0.74 L3MBTL1 (0.58) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL9967732 0.73 KMT2A (0.61) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL10611673 0.71 MAPK1 (0.56) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL28895677 0.70 KMT2A (0.62) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL20533743 0.70 KMT2A (0.55) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL3370446 0.70 KMT2A (0.58) L3MBTL1KMT2AMEN1LMNASMN1; SMN2
SCHEMBL11459158 0.70 SMN1; SMN2 (0.66) KMT2AMEN1LMNASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6337305-B1 HERBICIDES FOR AGRICULTURE BASF AKTIENGESELLSCHAFT (DE) 2002-01-08 US disclosed
EP-0968188-A1 SUBSTITUTED 2-BENZ(O)YLPYRIDINES, THEIR PREPARATION AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2000-01-05 EP disclosed
WO-1998042671-A1 SUBSTITUTED 2-BENZ(O)YLPYRIDINES, THEIR PREPARATION AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-10-01 WO disclosed