Sugi Predict

Sugi Predict / Compounds / SCHEMBL3370446

SCHEMBL3370446

SCHEMBL3370446

CC(N)c1ncc(C(F)(F)F)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.58
▸ MAPK1 P28482 1/20 0.56
▸ MEN1 O00255 2/20 0.52
▸ SMN1; SMN2 Q16637 4/20 0.52
▸ GAA P10253 3/20 0.52
▸ RAB9A P51151 1/20 0.52
▸ LMNA P02545 2/20 0.51
▸ ALDH1A1 P00352 4/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ HTT P42858 1/20 0.50
▸ MAPT P10636 2/20 0.49
▸ CRHBP P24387 1/20 0.49
▸ CRHR2 Q13324 1/20 0.49
▸ PKM P14618 1/20 0.48
▸ KDM4E B2RXH2 3/20 0.48
▸ PLAU P00749 1/20 0.47
▸ POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14920646 0.87 KMT2A (0.56) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL9967732 0.86 KMT2A (0.61) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL20533743 0.83 KMT2A (0.55) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL28895677 0.83 KMT2A (0.62) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL29106434 0.81 KMT2A (0.42) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL10611673 0.80 MAPK1 (0.56) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL29858300 0.80 MAPK1 (0.50) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL28824727 0.80 MAPK1 (0.50) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL10192289 0.80 KMT2A (0.56) KMT2AMAPK1MEN1SMN1; SMN2GAA
SCHEMBL4215795 0.79 KMT2A (0.41) KMT2AMAPK1MEN1SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117820206-A Synthesis method of polysubstituted pyridine ethyl-1-amine 上海罕道医药科技有限公司 2024-04-05 — — CN claimed
CN-117820206-A Synthesis method of polysubstituted pyridine ethyl-1-amine 上海罕道医药科技有限公司 2024-04-05 — — CN disclosed
CN-117820206-A Synthesis method of polysubstituted pyridine ethyl-1-amine 上海罕道医药科技有限公司 2024-04-05 — — CN disclosed
EP-3558944-B1 HYDROGENATION OF A SUBSTITUTED 2-METHYL CYANOPYRIDYL DERIVATIVE IN THE PRESENCE OF A RANEY COBALT CATALYST BAYER CROPSCIENCE AG (DE) 2022-03-09 — — EP disclosed
US-10766859-B2 Catalytic hydrogenation of nitriles BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-09-08 — — US disclosed
US-20200039936-A1 CATALYTIC HYDROGENATION OF NITRILES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-02-06 — — US disclosed
EP-3558944-A1 CATALYTIC HYDROGENATION OF NITRILES Bayer CropScience Aktiengesellschaft (DE) 2019-10-30 — — EP disclosed
US-10414730-B2 Catalytic hydrogenation of nitriles BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-09-17 — — US disclosed
US-20180244621-A1 CATALYTIC HYDROGENATION OF NITRILES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-08-30 — — US disclosed
WO-2018114810-A1 CATALYTIC HYDROGENATION OF NITRILES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-06-28 — — WO disclosed
EP-1966156-B1 NEW COMPOUNDS III ASTRAZENECA AB (SE) 2011-12-21 — — EP disclosed
EP-1204642-B1 FUNGICIDES BAYER CROPSCIENCE AG (DE) 2010-10-13 — — EP disclosed
US-7074742-B2 Pyridinyl amides and imides for use as fungicides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-07-11 — — US disclosed
CN-1688546-A Pyridinyl amides and imides for use as fungicides DU PONT (US) 2005-10-26 — — CN disclosed
CN-1665395-A Synergistic fungicide compositions containing at least one N-(2-pyridinyl) 1-3-pyridinecarboxamide derivative and one or more further fungicides useful for controlling fungal plant diseases DU PONT (US) 2005-09-07 — — CN disclosed
US-6939882-B1 Fungicides AVENTIS CROPSCIENCES GMBH (DE) 2005-09-06 — — US disclosed
US-20050009889-A1 Synergistic fungicide compositions containing at least one n-(2-pyridinyl) 1-3-pyridinecarboxamide derivative and one or more further fungicides useful for controlling fungal plant diseases E.I. DU PONE DE NEMOURS AND COMPANY 2005-01-13 — — US disclosed
US-20040044040-A1 Pyridinyl amides and imides for use as fungicides E. I. DU PONT DE NEMOURS AND COMPANY 2004-03-04 — — US disclosed
EP-1204642-A1 FUNGICIDES Aventis CropScience GmbH (DE) 2002-05-15 — — EP disclosed
WO-2001012604-A1 FUNGICIDES AVENTIS CROPSCIENCE GMBH (DE) 2001-02-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050009889-A1 Synergistic fungicide compositions containing at least one n-(2-pyridinyl) 1-3-pyridinecarboxamide derivative and one or more further fungicides useful for controlling fungal plant diseases CYC1, ME3, CYP11B1 KMT2A 2462/4885MAPK1 1882/4885MEN1 2003/4885
US-20040044040-A1 Pyridinyl amides and imides for use as fungicides CBR1, CBR3, AOC3 KMT2A 2759/4885MAPK1 1077/4885MEN1 2225/4885
US-10766859-B2 Catalytic hydrogenation of nitriles HNMT, NUP50, HCN2 KMT2A 1306/4885MAPK1 2256/4885MEN1 1429/4885
US-20180244621-A1 CATALYTIC HYDROGENATION OF NITRILES PNMT, HNMT, HPD KMT2A 477/4885MAPK1 2523/4885MEN1 2134/4885
US-20200039936-A1 CATALYTIC HYDROGENATION OF NITRILES HNMT, NUP50, HCN2 KMT2A 1306/4885MAPK1 2256/4885MEN1 1429/4885
US-10414730-B2 Catalytic hydrogenation of nitriles PNMT, HNMT, HPD KMT2A 477/4885MAPK1 2523/4885MEN1 2134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.