Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.75 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.75 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.75 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.75 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | PNP | P00491 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3757546 | 0.87 | FGFR1 (0.59) | GRIA1GRIA2GRIA3GRIA4FGFR1 | |
| SCHEMBL14716577 | 0.82 | FGFR1 (0.56) | GRIA1GRIA2GRIA3GRIA4FGFR1 | |
| Biphenyl SCHEMBL27410122 | 0.81 | PNP (0.79) | GRIA1GRIA2GRIA3GRIA4FGFR1 | |
| SCHEMBL6783434 | 0.76 | GRIA1 (0.59) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7688479 | 0.74 | ADORA2B (0.46) | GRIA1GRIA2GRIA3GRIA4FGFR1 | |
| Xanthine SCHEMBL29180270 | 0.74 | PNP (0.62) | GRIA1GRIA2GRIA3GRIA4PNP | |
| SCHEMBL5084818 | 0.74 | PNP (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL5998047 | 0.74 | XDH (0.52) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL1286929 | 0.74 | PNP (0.50) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL1286951 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-108703970-A | Compound for activating AMPK and application thereof | 华安医学股份有限公司 | 2018-10-26 | — | — | CN | disclosed |
| CN-104447746-A | Compound for activating AMPK and application thereof | HUAAN MEDICAL CO LTD | 2015-03-25 | — | — | CN | disclosed |
| CN-1410059-A | Treating method and medicine kit containing somatotrophic hormone secretory agent | PFIZER PRODUCT CO (US) | 2003-04-16 | — | — | CN | disclosed |
| WO-2002085904-A1 | SNYTHESIS AND METHODS OF USE OF PURINE ANALOGUES AND DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |
| US-20020156277-A1 | Synthesis and methods of use of purine analogues and derivatives | NEO THERAPEUTICS, INC. | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156277-A1 | Synthesis and methods of use of purine analogues and derivatives | SLC29A1, ATIC, PNP | GRIA1 900/4885GRIA2 1688/4885GRIA3 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.