Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569493 | 0.73 | ROCK1 (0.47) | MAPTRAB9AHDAC11HDAC6MEN1 | |
| SCHEMBL570508 | 0.71 | MAPT (0.36) | MAPTRAB9APDE10ASMN1; SMN2MEN1 | |
| SCHEMBL1701449 | 0.71 | PDE10A (0.37) | MAPTRAB9APDE10AFAAHSMN1; SMN2 | |
| SCHEMBL7694281 | 0.70 | SYK (0.42) | SYKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL7689084 | 0.70 | GRM5 (0.45) | GRM5SMN1; SMN2 | |
| SCHEMBL1018884 | 0.70 | ALDH1A1 (0.53) | MAPTRAB9APDE10ASMN1; SMN2HDAC11 | |
| SCHEMBL12473779 | 0.67 | ACSS2 (0.39) | MAPTRAB9ASMN1; SMN2HDAC11HDAC6 | |
| SCHEMBL14889094 | 0.67 | ACHE (0.36) | MAPTRAB9ASMN1; SMN2HDAC11HDAC6 | |
| SCHEMBL7702320 | 0.66 | GRM5 (0.41) | GRM5MAPTRAB9APDE10ASMN1; SMN2 | |
| SCHEMBL7688852 | 0.63 | GRM5 (0.55) | GRM5MAPTRAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |