Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | HTR2B | P41595 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | EIF2AK3 | Q9NZJ5 | 5/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12359781 | 0.74 | CHRM4 (0.49) | GPR119 | |
| SCHEMBL12165109 | 0.74 | MPO (0.42) | SYKJAK2PLK1GPR119EGFR | |
| SCHEMBL1165336 | 0.73 | EGFR (0.42) | SYKPLK1GPR119EGFR | |
| SCHEMBL12464373 | 0.72 | ALDH1A1 (0.53) | GPR119 | |
| SCHEMBL16150001 | 0.72 | EIF2AK3 (0.66) | EGFRERBB2ERBB4EIF2AK3 | |
| SCHEMBL1058729 | 0.72 | ALDH1A1 (0.46) | GPR119 | |
| SCHEMBL7880759 | 0.71 | LMNA (0.42) | HTR2BHTR2A | |
| SCHEMBL1051317 | 0.70 | RAB9A (0.60) | — | |
| SCHEMBL12165013 | 0.70 | PLK1 (0.38) | SYKJAK2JAK3PTK2HTR2C | |
| SCHEMBL2581787 | 0.70 | EGFR (0.40) | SYKHTR2CPLK1GPR119EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |