Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26248640 | 0.84 | ALDH1A1 (0.47) | ALDH1A1PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL2115743 | 0.72 | ALDH1A1 (0.52) | ALDH1A1ADORA2BADORA2AATAD2PDE4A | |
| SCHEMBL7688731 | 0.70 | MEN1 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8354950 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL94914 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL18560720 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PDPK1LRRK2ADORA2BADORA2A | |
| SCHEMBL16513159 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL612165 | 0.68 | ALDH1A1 (0.52) | ALDH1A1PDPK1CHEK1AURKACHEK2 | |
| SCHEMBL26248657 | 0.68 | ALDH1A1 (0.47) | ALDH1A1ADORA2BADORA2APDE4APDE4B | |
| SCHEMBL1866522 | 0.66 | PDE4A (0.49) | ALDH1A1ADORA2BADORA2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002085904-A1 | SNYTHESIS AND METHODS OF USE OF PURINE ANALOGUES AND DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |
| US-20020156277-A1 | Synthesis and methods of use of purine analogues and derivatives | NEO THERAPEUTICS, INC. | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156277-A1 | Synthesis and methods of use of purine analogues and derivatives | SLC29A1, ATIC, PNP | ALDH1A1 834/4885PDPK1 1997/4885CHEK1 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.