Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 4/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689368 | 0.79 | PIM1 (0.45) | TP53ALDH1A1MAPK1PIM1CLK4 | |
| SCHEMBL7683237 | 0.78 | SMN1; SMN2 (0.48) | TP53ALDH1A1MAPK1PIM1CLK4 | |
| Hydrochloric Acid SCHEMBL7687660 | 0.78 | PIM1 (0.44) | TP53ALDH1A1MAPK1PIM1CLK4 | |
| SCHEMBL6804202 | 0.75 | LMNA (0.30) | HSD17B10LMNA | |
| SCHEMBL7689241 | 0.75 | HCAR2 (0.48) | TP53ALDH1A1ALPLALOX15TSHR | |
| Hydrochloric Acid SCHEMBL7689302 | 0.74 | LMNA (0.30) | HSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL7689305 | 0.74 | LMNA (0.30) | HSD17B10LMNA | |
| SCHEMBL7683192 | 0.73 | ALDH1A1 (0.33) | TP53ALDH1A1ALPLMAPK1PIM1 | |
| SCHEMBL7682852 | 0.73 | HSD17B10 (0.39) | TP53ALDH1A1ALPLALOX15TSHR | |
| SCHEMBL7678938 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |