Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76522 | 0.94 | LMNA (0.50) | LMNATP53RAB9AMEN1KMT2A | |
| SCHEMBL77141 | 0.90 | TDP1 (0.52) | LMNAMEN1KMT2ACES2CES1 | |
| SCHEMBL6707539 | 0.83 | ALDH1A1 (0.48) | LMNATP53MEN1KMT2AL3MBTL1 | |
| SCHEMBL13052942 | 0.79 | TDP1 (0.55) | LMNARAB9ANPC1CES2CES1 | |
| SCHEMBL28457962 | 0.79 | TDP1 (0.55) | LMNARAB9ANPC1CES2CES1 | |
| SCHEMBL29291328 | 0.79 | LMNA (0.52) | LMNATP53RAB9AMEN1KMT2A | |
| SCHEMBL28272245 | 0.79 | ALDH1A1 (0.56) | LMNATP53MEN1KMT2AL3MBTL1 | |
| SCHEMBL31258304 | 0.77 | MAPT (0.51) | LMNATP53RAB9AMEN1KMT2A | |
| SCHEMBL4250144 | 0.77 | SRC (0.52) | LMNAKMT2AALDH1A1HPGDMAPK1 | |
| SCHEMBL627377 | 0.77 | SRC (0.52) | LMNAKMT2AALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | disclosed |