SCHEMBL7689604

SCHEMBL7689604

CCOC(=O)C1=C(CC)NC(c2ccccc2)=C(C(=O)OCC)C1C

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 9/20 0.65
ALDH1A1 P00352 4/20 0.61
CACNA1D Q01668 2/20 0.58
TMIGD3 P0DMS9 1/20 0.53
TRPV1 Q8NER1 3/20 0.52
LMNA P02545 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MAPK1 P28482 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
HTT P42858 2/20 0.48
ALOX12 P18054 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA7 P43166 1/20 0.47
CA9 Q16790 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7687629 0.86 ADORA3 (0.75) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL8210401 0.81 ADORA3 (0.49) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL7685244 0.80 ADORA3 (0.67) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL6374693 0.80 ADORA3 (1.00) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL19590936 0.76 ALDH1A1 (1.00) ADORA3ALDH1A1TRPV1LMNASMN1; SMN2
SCHEMBL7680777 0.75 ADORA3 (1.00) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL1664685 0.74 ADORA3 (0.71) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL9062922 0.74 ADORA3 (0.66) ADORA3ALDH1A1CACNA1DLMNAMAPK1
SCHEMBL7685108 0.73 ADORA3 (0.74) ADORA3ALDH1A1CACNA1DTMIGD3TRPV1
SCHEMBL24624914 0.72 ALDH1A1 (0.83) ALDH1A1MAPK1SMN1; SMN2HTTCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US claimed
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US disclosed
WO-2000002861-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-20 WO disclosed