Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.74 |
| ▸ | DHFR | P00374 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | CA2 | P00918 | 4/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.63 |
| ▸ | CA7 | P43166 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419868 | 0.91 | GAA (0.70) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL4669190 | 0.91 | ALDH1A1 (0.67) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL26671671 | 0.84 | ALDH1A1 (0.64) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL3168404 | 0.82 | CA1 (0.79) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL10279642 | 0.82 | DHFR (0.74) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL5380810 | 0.82 | DHFR (0.79) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL26671696 | 0.81 | ALDH1A1 (0.60) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL29793923 | 0.81 | ALDH1A1 (0.60) | GUSBDHFRCA1CA2CA12 | |
| SCHEMBL10112977 | 0.81 | DHFR (0.72) | DHFRCA1CA2CA12CA7 | |
| SCHEMBL28558189 | 0.81 | DHFR (0.81) | DHFRCA1CA2CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |