Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7692247 | 0.83 | SNCA (0.45) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL7685864 | 0.82 | SNCA (0.59) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL7692046 | 0.82 | SNCA (0.59) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL7695841 | 0.79 | NOX1 (0.49) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL7690172 | 0.79 | NOX1 (0.41) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL3489840 | 0.77 | SNCA (1.00) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL29636455 | 0.77 | SNCA (1.00) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL17289246 | 0.73 | SNCA (0.83) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL4080414 | 0.70 | NOX1 (1.00) | SNCAMEN1MAPTKMT2ANOX1 | |
| SCHEMBL7685434 | 0.70 | NOX1 (0.38) | SNCAMAPTNOX1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539202-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1163233-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-12-19 | — | — | EP | claimed |
| WO-2000055147-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-09-21 | — | — | WO | claimed |
| EP-1163233-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055147-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-09-21 | — | — | WO | disclosed |