SCHEMBL769183

SCHEMBL769183

CCn1nc(C(F)(F)F)cc1C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.41
GRIA2 P42262 2/20 0.39
MPO P05164 1/20 0.38
KDM4E B2RXH2 4/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
TP53 P04637 1/20 0.35
TGFBR1 P36897 1/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
KMT2A Q03164 1/20 0.35
POLB P06746 1/20 0.35
TSHR P16473 1/20 0.35
RAD51 Q06609 1/20 0.35
TRPC3 Q13507 1/20 0.34
STIM1 Q13586 1/20 0.34
ORAI1 Q96D31 1/20 0.34
CNR1 P21554 1/20 0.33
CNR2 P34972 1/20 0.33
ADORA2A P29274 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12859150 0.89 LMNA (0.39) LMNAGRIA2MPOKDM4EL3MBTL1
SCHEMBL21848996 0.89 GRN (0.36) LMNAGRIA2MPOKDM4ETGFBR1
SCHEMBL13683165 0.85 TGFBR1 (0.42) LMNAGRIA2MPOKDM4EL3MBTL1
SCHEMBL20381740 0.82 CNR1 (0.47) LMNAGRIA2KDM4EL3MBTL1CNR1
SCHEMBL14043795 0.80 ASAH1 (0.42) LMNAKDM4ETP53MAPTMEN1
SCHEMBL8322070 0.80 LMNA (0.55) LMNAKDM4EL3MBTL1TP53MEN1
SCHEMBL20032026 0.79 GRIA2 (0.37) LMNAGRIA2MPOKDM4EL3MBTL1
SCHEMBL6525164 0.78 MPO (0.34) LMNAMPOKDM4EL3MBTL1ALDH1A1
SCHEMBL21863509 0.78 BRD9 (0.35) CNR1CNR2ADORA2AADORA2B
SCHEMBL26033956 0.78 CYP3A4 (0.36) LMNAGRIA2MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2398778-B1 AMINOPYRIDINEAMIDES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2014-03-26 EP disclosed
US-20120071496-A1 Aminopyrimidinamides As Pest Control Agents BAYER CROPSCIENCE AG (DE) 2012-03-22 US disclosed
EP-2246335-A1 Aminopyridineamides as pesticides Bayer CropScience AG (DE) 2010-11-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071496-A1 Aminopyrimidinamides As Pest Control Agents NPEPPS, DDT, DNPEP LMNA 4139/4885GRIA2 1019/4885MPO 2925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.