Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689434 | 0.82 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7689815 | 0.81 | HDAC1 (0.42) | NPC1RAB9ASMN1; SMN2LMNAUSP2 | |
| SCHEMBL7694873 | 0.77 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7702048 | 0.75 | HTR1A (0.39) | NPC1RAB9AMAPK1HDAC1NPSR1 | |
| SCHEMBL7694134 | 0.73 | HDAC1 (0.37) | NPC1RAB9AMAPTHDAC1ALDH1A1 | |
| SCHEMBL7702938 | 0.72 | HDAC1 (0.43) | MAPTMAPK1HDAC1ALDH1A1KDM4E | |
| SCHEMBL4745433 | 0.72 | NR5A1 (0.51) | MAPT | |
| SCHEMBL9699146 | 0.72 | NR5A1 (0.51) | MAPT | |
| SCHEMBL4090434 | 0.72 | TDP1 (0.51) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL4748690 | 0.72 | NR5A1 (0.51) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002024619-A1 | AMINE COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |