SCHEMBL769249

SCHEMBL769249

N#Cc1ccc(-c2ccccc2)cc1C#N

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.62
KDM4E B2RXH2 4/20 0.62
LMNA P02545 2/20 0.62
HTT P42858 1/20 0.62
RXFP1 Q9HBX9 1/20 0.62
THRB P10828 1/20 0.62
MAOB P27338 8/20 0.57
MAOA P21397 6/20 0.57
MCL1 Q07820 2/20 0.55
CYP11B1 P15538 1/20 0.54
CYP11B2 P19099 1/20 0.54
HPGD P15428 3/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
MAPK1 P28482 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
GLA P06280 1/20 0.49
GAA P10253 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18411360 0.96 ALDH1A1 (0.59) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL18411426 0.96 ALDH1A1 (0.59) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL30542183 0.93 ALDH1A1 (0.55) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL15484269 0.93 ALDH1A1 (0.55) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL8420988 0.91 ALDH1A1 (0.50) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL25544760 0.89 ALDH1A1 (0.53) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL25543638 0.89 ALDH1A1 (0.53) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL16277098 0.88 ALDH1A1 (0.52) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL15775864 0.88 MCL1 (0.53) ALDH1A1KDM4ELMNAHTTRXFP1
SCHEMBL18411424 0.85 ALDH1A1 (0.57) ALDH1A1KDM4ELMNAHTTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101068773-A Melanin concentrating hormone antagonists PROCTER & GAMBLE (US) 2007-11-07 CN claimed
EP-1667958-A2 MELANIN CONCENTRATING HORMONE ANTAGONISTS THE PROCTER & GAMBLE COMPANY (US) 2006-06-14 EP claimed
WO-2005033063-A2 MELANIN CONCENTRATING HORMONE ANTAGONISTS THE PROCTER & GAMBLE COMPANY (US) 2005-04-14 WO claimed
US-20050075324-A1 Melanin concentrating hormone antagonists THE PROCTER & GAMBLE COMPANY (US) 2005-04-07 US claimed
US-11746262-B2 Phthalonitrile adhesive formulations and related methods THE BOEING COMPANY (US) 2023-09-05 US disclosed
US-20230145826-A1 FLUORESCENT LABELING AGENT AND FLUORESCENT DYE TOYO INK SC HOLDINGS CO., LTD. (JP) 2023-05-11 US disclosed
US-20230145826-A1 FLUORESCENT LABELING AGENT AND FLUORESCENT DYE TOYO INK SC HOLDINGS CO., LTD. (JP) 2023-05-11 US disclosed
CN-115776890-A TRPV4 inhibitors as therapeutic agents for eye diseases 拉夸里亚创药株式会社 2023-03-10 CN disclosed
EP-4130163-A1 FLUORESCENT LABELING AGENT AND FLUORESCENT DYE Toyo Ink SC Holdings Co., Ltd. (JP) 2023-02-08 EP disclosed
US-11444250-B2 Composition of matter for use in organic light-emitting diodes KYULUX, INC. (JP) 2022-09-13 US disclosed
US-20210340413-A1 PHTHALONITRILE ADHESIVE FORMULATIONS AND RELATED METHODS THE BOEING COMPANY 2021-11-04 US disclosed
US-10043983-B2 Condensed cyclic compound and organic light-emitting device including the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2018-08-07 US disclosed
US-7304065-B2 Melanin concentrating hormone antagonists THE PROCTER & GAMBLE COMPANY (US) 2007-12-04 US disclosed
US-20060247239-A1 Melanin concentrating hormone antagonists HU XIUFENG E 2006-11-02 US disclosed
US-20050075324-A1 Melanin concentrating hormone antagonists THE PROCTER & GAMBLE COMPANY (US) 2005-04-07 US disclosed
CN-1245516-A Method for preparing light-absorbing polymer composition EASTMAN CHEM CO (US) 2000-02-23 CN disclosed
US-4645821-A Precursor of copolyphthalocyanine-imide lattice, preparation, and the resultant lattice CENTRE D'ETUDE DES MATERIAUX ORGANIQUES POUR TECHNOLOGIES AVANCEES (FR) 1987-02-24 US disclosed
EP-0042531-B1 ISOINDOLINE DERIVATIVES AND THEIR USES AS INTERMEDIATES IN THE PREPARATION OF DYESTUFFS BAYER AG (DE) 1984-02-08 EP disclosed
US-4145264-A AROMATIC O-DICARBOXYLIC ACID NITRILES ELECTROLYZED IN AN ORGANIC LIQUID WITH AN ALKALINE ACTIVATOR BASF AKTIENGESELLSCHAFT (DE) 1979-03-20 US disclosed
US-3994921-A COLORING PLASTICS AND LACQUERS YELLOW CIBA-GEIGY CORPORATION (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10043983-B2 Condensed cyclic compound and organic light-emitting device including the same CRY1, CCNE1, CRY2 ALDH1A1 2084/4885KDM4E 3085/4885LMNA 1207/4885
US-20050075324-A1 Melanin concentrating hormone antagonists MCHR1, MCHR2, MC1R ALDH1A1 3383/4885KDM4E 3266/4885LMNA 4834/4885
US-20060247239-A1 Melanin concentrating hormone antagonists MCHR1, MCHR2, MC1R ALDH1A1 3383/4885KDM4E 3266/4885LMNA 4834/4885
US-11444250-B2 Composition of matter for use in organic light-emitting diodes CRY2, ALDH1A2, CYBA ALDH1A1 60/4885KDM4E 4374/4885LMNA 1149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.