Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327385 | 0.89 | CHRM1 (0.52) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| Bromide SCHEMBL5227189 | 0.84 | HTR4 (0.51) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL16079061 | 0.84 | ALDH1A1 (0.45) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL22168402 | 0.82 | POLB (0.46) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL24003465 | 0.81 | POLB (0.54) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL12324733 | 0.80 | ITGB3 (0.52) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL26374152 | 0.79 | GNAO1 (0.57) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL5337084 | 0.79 | CHRM1 (0.48) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL20374733 | 0.78 | GNAO1 (0.60) | CHRM1CHRM2CHRM4CHRM5DRD2 | |
| SCHEMBL25654123 | 0.78 | GNAO1 (0.65) | CHRM1CHRM2CHRM4CHRM5DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |