Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911863 | 0.82 | TDP1 (0.54) | TDP1GPR35HSD17B10ALDH1A1GLA | |
| SCHEMBL1807309 | 0.79 | TDP1 (0.62) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL14028230 | 0.79 | GPR35 (0.55) | KMT2AMEN1TDP1GPR35MAPT | |
| SCHEMBL4946630 | 0.79 | GPR35 (0.55) | KMT2AMEN1TDP1GPR35MAPT | |
| SCHEMBL7534908 | 0.76 | GPR35 (0.62) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL9101870 | 0.75 | KMT2A (0.47) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL9101872 | 0.75 | KMT2A (0.47) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL1548597 | 0.75 | FBP1 (0.45) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL4875174 | 0.75 | KMT2A (0.44) | KMT2AMEN1F2PRSS1PRSS2 | |
| SCHEMBL4158554 | 0.75 | KMT2A (0.70) | KMT2AMEN1F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002081466-A1 | PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES | SUGEN, INC. (US) | 2002-10-17 | — | — | WO | disclosed |