Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.58 |
| ▸ | MMP9 | P14780 | 7/20 | 0.58 |
| ▸ | MMP8 | P22894 | 6/20 | 0.58 |
| ▸ | MMP13 | P45452 | 4/20 | 0.58 |
| ▸ | MMP1 | P03956 | 2/20 | 0.58 |
| ▸ | MMP14 | P50281 | 2/20 | 0.58 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
| ▸ | MMP16 | P51512 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.54 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.49 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695749 | 1.00 | MMP2 (0.58) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL7446097 | 0.91 | KEAP1 (0.49) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL8016350 | 0.89 | BMP1 (0.51) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL8521366 | 0.86 | MMP2 (0.60) | MMP2MMP9MMP8MMP13MMP1 | |
| SCHEMBL6389641 | 0.83 | TAS2R14 (0.58) | MMP2MMP9MMP8MMP13TAS2R14 | |
| SCHEMBL6389646 | 0.83 | TAS2R14 (0.58) | MMP2MMP9MMP8MMP13TAS2R14 | |
| SCHEMBL6391015 | 0.79 | MMP2 (0.48) | MMP2MMP9MMP8MMP13KEAP1 | |
| SCHEMBL6391009 | 0.79 | MMP2 (0.48) | MMP2MMP9MMP8MMP13KEAP1 | |
| SCHEMBL7091056 | 0.78 | MMP2 (0.76) | MMP2MMP9MMP8MMP13KEAP1 | |
| SCHEMBL7091051 | 0.78 | MMP2 (0.76) | MMP2MMP9MMP8MMP13KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380219-B1 | FOR THERAPY OF ARTHRITIS, CANCER, TISSUE ULCERATION, RESTENOSIS, PERIDONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE ACTIVITY, SEPSIS, SEPTIC SHOCK | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| US-5863949-A | Arylsulfonylamino hydroxamic acid derivatives | PFIZER INC (US) | 1999-01-26 | — | — | US | disclosed |