Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 17/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157095 | 0.70 | — | — | |
| SCHEMBL201520 | 0.67 | ACACB (0.45) | ICMTCNR2TSHRHSD17B10 | |
| SCHEMBL7222725 | 0.67 | TLR8 (0.44) | TLR8TSHRHSD17B10 | |
| SCHEMBL2791515 | 0.66 | KDM4E (0.36) | TLR8HSD17B10 | |
| SCHEMBL8652248 | 0.66 | NPC1 (0.49) | ICMTTSHRHSD17B10 | |
| SCHEMBL5796848 | 0.64 | CYP19A1 (0.39) | TSHRHSD17B10 | |
| SCHEMBL1155792 | 0.62 | KIF11 (0.31) | — | |
| SCHEMBL3618459 | 0.62 | TLR8 (0.50) | TLR8 | |
| SCHEMBL24885636 | 0.61 | TLR8 (0.57) | TLR8ICMTTSHRHSD17B10 | |
| SCHEMBL9684661 | 0.61 | GRK6 (0.39) | TLR8TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| CN-1142817-A | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof | DU PONT MERCK PHARMA (US) | 1997-02-12 | — | — | CN | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |