Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690235 | 0.74 | ALDH1A1 (0.57) | ALDH1A1ALOX12TP53GAAL3MBTL1 | |
| SCHEMBL7697114 | 0.73 | EPHX2 (0.54) | ALDH1A1ALOX12TP53LMNACYP2C9 | |
| SCHEMBL12595250 | 0.71 | TRPA1 (0.53) | ALDH1A1ALOX12TP53LMNACYP2C9 | |
| SCHEMBL10113819 | 0.71 | ALDH1A1 (0.69) | ALDH1A1ALOX12TP53LMNACYP2C9 | |
| SCHEMBL7690425 | 0.71 | ALDH1A1 (0.63) | ALDH1A1ALOX12TP53CYP2C9CYP2C19 | |
| SCHEMBL10113034 | 0.70 | DHFR (0.76) | ALDH1A1ALOX12LMNACYP2C9CYP2C19 | |
| SCHEMBL31488632 | 0.70 | ALDH1A1 (0.56) | ALDH1A1ALOX12TP53CYP2C9CYP2C19 | |
| SCHEMBL7688985 | 0.70 | ALDH1A1 (0.46) | ALDH1A1ALOX12TP53LMNACYP2C9 | |
| SCHEMBL13419898 | 0.69 | DHFR (0.74) | ALDH1A1CYP2C9CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7693844 | 0.69 | ALDH1A1 (0.58) | ALDH1A1ALOX12TP53CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | claimed |
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |