Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143195 | 0.88 | FFAR1 (0.39) | FFAR1LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL7707062 | 0.83 | L3MBTL1 (0.38) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7704027 | 0.83 | FFAR1 (0.49) | FFAR1LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL6610351 | 0.78 | MAPT (0.42) | FFAR1LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL15459105 | 0.75 | FFAR1 (0.52) | FFAR1MAPTSMN1; SMN2NPC1KMT2A | |
| SCHEMBL7698560 | 0.75 | DHODH (0.38) | LMNAMAPTMAPK1KMT2AMEN1 | |
| SCHEMBL7146760 | 0.75 | ALDH1A1 (0.39) | LMNAHTTMAPTSMN1; SMN2NPC1 | |
| SCHEMBL7704399 | 0.75 | FFAR1 (0.40) | FFAR1LMNARAB9AKMT2APTGDR2 | |
| SCHEMBL7138020 | 0.74 | ALDH1A1 (0.39) | HTTMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7143531 | 0.74 | ALDH1A1 (0.41) | LMNAHTTMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |