Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.54 |
| ▸ | SLC9A1 | P19634 | 7/20 | 0.49 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.41 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | DRD3 | P35462 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28140958 | 1.00 | MTNR1B (0.54) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| SCHEMBL7697047 | 1.00 | MTNR1B (0.54) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| SCHEMBL27871504 | 0.81 | MTNR1B (0.51) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| SCHEMBL8489075 | 0.81 | MTNR1B (0.56) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| SCHEMBL8486710 | 0.80 | KDM1A (0.41) | MTNR1BDRD2MTNR1A | |
| SCHEMBL8486713 | 0.80 | KDM1A (0.41) | MTNR1BDRD2MTNR1A | |
| SCHEMBL8489071 | 0.78 | SLC9A1 (0.53) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| SCHEMBL9926870 | 0.77 | MTNR1B (0.66) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 | |
| Methylamine SCHEMBL22076722 | 0.77 | SLC9A1 (0.53) | MTNR1BSLC9A1SLC9A5SLC9A2HTR2A | |
| SCHEMBL19226925 | 0.77 | MTNR1B (0.66) | MTNR1BSLC9A1SLC9A5SLC9A2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106543119-B | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2019-07-26 | — | — | CN | claimed |
| CN-106543119-A | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2017-03-29 | — | — | CN | claimed |
| CN-106543119-B | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2019-07-26 | — | — | CN | disclosed |
| CN-106543119-A | Preparation method of optically pure tasimelteon | 浙江工业大学 | 2017-03-29 | — | — | CN | disclosed |
| EP-1082115-A4 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-10-24 | — | — | EP | disclosed |
| US-6214869-B1 | SLEEP DISORDERS | BRISTOL-MYERS SQUIBB | 2001-04-10 | — | — | US | disclosed |
| EP-1082115-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062515-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-09 | — | — | WO | disclosed |