Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7692176 | 0.80 | TSHR (0.38) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL4726369 | 0.76 | CA12 (0.41) | RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL7989497 | 0.75 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL7989499 | 0.75 | RAB9A (0.41) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL20570815 | 0.74 | TSHR (0.53) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1HPGD | |
| SCHEMBL27970370 | 0.73 | TSHR (0.51) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1HPGD | |
| SCHEMBL900423 | 0.72 | RAB9A (0.36) | RAB9ANPC1SMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL29291579 | 0.70 | TSHR (0.54) | RAB9ANPC1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL29126825 | 0.69 | ALDH1A1 (0.55) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6343556 | 0.68 | EPHX1 (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |