SCHEMBL7703155

SCHEMBL7703155

CCOC(=O)c1cc(COC)nn1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 5/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
MAPT P10636 1/20 0.46
KDM4E B2RXH2 3/20 0.44
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CDK2 P24941 6/20 0.40
CCNE1 P24864 5/20 0.40
GSK3B P49841 3/20 0.40
FAAH O00519 2/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
CDK1 P06493 1/20 0.40
CDK4 P11802 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22286911 0.86 CA12 (0.42) SMN1; SMN2NPC1RAB9AMAPTKDM4E
SCHEMBL973113 0.86 LMNA (0.50) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL7699075 0.84 LMNA (0.49) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL5900613 0.83 LMNA (0.48) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL859 0.83 POLB (0.50) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL25348368 0.83 SMN1; SMN2 (0.45) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL26964748 0.83 RAB9A (0.45) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL26105035 0.83 FAAH (0.44) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL24914932 0.82 LMNA (0.43) LMNASMN1; SMN2NPC1RAB9AMAPT
SCHEMBL26964701 0.82 RAB9A (0.44) LMNASMN1; SMN2NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023141852-A1 CDK2 INHIBITORS, PREPARATION METHOD THEREFOR AND USE THEREOF 益方生物科技(上海)股份有限公司 2023-08-03 WO disclosed
EP-0901488-B1 2,4-DIAMINOPYRIMIDINE DERIVATIVES BASILEA PHARMACEUTICA AG (CH) 2002-11-06 EP disclosed
EP-0901488-A1 2,4-DIAMINOPYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-03-17 EP disclosed
US-5866583-A Substituted 2,4-diaminopyrimidines HOFFMANN-LA ROCHE INC. (US) 1999-02-02 US disclosed
WO-1997043277-A1 2,4-DIAMINOPYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-11-20 WO disclosed