⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185151 | 0.81 | LMNA (0.43) | — | |
| SCHEMBL7665824 | 0.79 | — | — | |
| SCHEMBL9529885 | 0.77 | — | — | |
| SCHEMBL455750 | 0.77 | — | — | |
| SCHEMBL5851796 | 0.77 | — | — | |
| SCHEMBL20486245 | 0.77 | — | — | |
| SCHEMBL2912097 | 0.74 | — | — | |
| SCHEMBL9322491 | 0.74 | LMNA (0.31) | — | |
| SCHEMBL7465411 | 0.74 | CALM1 (0.44) | — | |
| SCHEMBL10531181 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3937943-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | The General Hospital Corporation (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |
| CN-105658630-A | Tetrazolinone compound and use thereof | 住友化学株式会社 | 2016-06-08 | — | — | CN | disclosed |
| WO-2002057258-A1 | CYCLO`D!AZEPANE DERIVATIVES WHICH ARE USED AS FARNESYLTRANSFERASE INHIBITORS AND METHOD FOR THE PREPARATION THEREOF | LES LABORATOIRES SERVIER (FR) | 2002-07-25 | — | — | WO | disclosed |