Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386441 | 0.86 | SLC18A2 (0.36) | CYP1A2TSHR | |
| SCHEMBL7377008 | 0.85 | HTR1A (0.44) | CYP3A4CYP2D6HSD17B10HTR1A | |
| SCHEMBL7384142 | 0.73 | ADRA2A (0.39) | CYP1A2TSHR | |
| SCHEMBL7694457 | 0.72 | CA1 (0.39) | CYP1A2TSHRMAPK1HSD17B10 | |
| SCHEMBL7701247 | 0.72 | PDCD1 (0.35) | — | |
| SCHEMBL7377280 | 0.72 | KDM4E (0.42) | CYP3A4TSHR | |
| SCHEMBL7700908 | 0.71 | SLC18A2 (0.36) | SLC6A4SLC6A2CYP1A2TSHRHSD17B10 | |
| SCHEMBL7388475 | 0.70 | NLRP3 (0.36) | SLC6A4SLC6A2SLC6A3CYP1A2TSHR | |
| SCHEMBL19053757 | 0.70 | ADRA2A (0.38) | — | |
| SCHEMBL7417781 | 0.69 | TSHR (0.41) | SLC6A4SLC6A2SLC6A3CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346527-B1 | 1-BENZOXEPIN DERIVATIVES USED IN THE PREVENTION OF SODIUM AND HYDROGEN ION EXCHANGE; CARDIOVASCULAR, KIDNEY AND BRAIN DISORDER TREATMENT; ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-12 | — | — | US | disclosed |
| EP-1073650-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055690-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-04 | — | — | WO | disclosed |