Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381743 | 0.86 | ALDH1A1 (0.44) | MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL914231 | 0.79 | CYP19A1 (0.43) | MAPTKDM4EALDH1A1ITGA4 | |
| SCHEMBL7387427 | 0.73 | ALDH1A1 (0.46) | MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL7381949 | 0.73 | MAPT (0.41) | MAPTPOLBKDM4ELMNAALDH1A1 | |
| SCHEMBL7703383 | 0.72 | ALDH1A1 (0.45) | MAPTKDM4EALDH1A1 | |
| SCHEMBL7701240 | 0.72 | SLC6A4 (0.33) | — | |
| SCHEMBL7537264 | 0.72 | ALDH1A1 (0.44) | MAPTPOLBKDM4ELMNAALDH1A1 | |
| SCHEMBL7376997 | 0.71 | RAB9A (0.44) | MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL10334508 | 0.70 | IMPDH2 (0.41) | MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL915090 | 0.70 | MAOB (0.38) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346527-B1 | 1-BENZOXEPIN DERIVATIVES USED IN THE PREVENTION OF SODIUM AND HYDROGEN ION EXCHANGE; CARDIOVASCULAR, KIDNEY AND BRAIN DISORDER TREATMENT; ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-12 | — | — | US | disclosed |
| EP-1073650-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055690-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-04 | — | — | WO | disclosed |